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Tapentadol is a centrally acting opioid analgesic medication used to treat moderate to severe pain. Palexia and Nucynta are just two of the brand names under which it is available. Tapentadol operates through binding to opioid receptors in the brain and spinal cord and inhibiting both mu-opioid receptor agonist activity and norepinephrine reuptake. Tapentadol is often prescribed as a pain reliever in neuropathic, musculoskeletal, and postoperative conditions. In light of its unique mechanism of action and possible mitigation of specific side effects like dyspepsia and respiratory depression, it is considered a substitute for other opioid medications.

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