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Tramadol is a centrally acting opioid analgesic used to manage moderate to moderately severe pain. It is chemically related to codeine and acts on the central nervous system to relieve pain. Tramadol is available in both immediate-release and extended-release formulations.

Tramadol works through two mechanisms:

1. μ-Opioid Receptor Agonism: Tramadol primarily exerts its analgesic effects by binding to μ-opioid receptors in the brain and spinal cord, which inhibits the transmission of pain signals and alters the perception of pain.

2. Serotonin and Norepinephrine Reuptake Inhibition (SNRI): Tramadol also inhibits the reuptake of serotonin and norepinephrine, which are neurotransmitters involved in mood regulation and the modulation of pain signals. This dual mechanism of action contributes to tramadol's pain-relieving properties.