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Tramadol is often preferred for moderate to moderately severe pain management due to its dual mechanism of action, which includes opioid receptor binding and inhibition of serotonin and norepinephrine reuptake. It can be used for various types of pain, including acute and chronic conditions. It is often used to manage pain following surgical procedures.

It can help control pain during the immediate postoperative period and during the early stages of recovery. Tramadol may be prescribed for long-term pain management in conditions such as arthritis, fibromyalgia, neuropathic pain, and other chronic pain syndromes. It can provide relief for persistent pain that affects daily functioning.